Cyclobenzaprine: Uses, Interactions, Mechanism of Action DrugBank Online

It works in the central nervous system (CNS) to relieve muscle pain and spasms. Cyclobenzaprine is available in immediate-release and extended-release forms. Now, skeletal muscle relaxants can further be divided into centrally-acting and direct-acting muscle relaxants.

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Butalbital, acetaminophen, and caffeine combination is used to relieve symptoms of tension (or muscle contraction) headaches. Generic Robaxin tablets are usually covered by Medicare and insurance plans. A SingleCare discount card can lower this price to $8 at participating pharmacies. Patients should avoid activities requiring mental alertness or coordination until drug effects are known, as drug may cause dizziness or sedative effects. Available as cyclobenzaprine hydrochloride; dosage expressed in terms of the salt.

Frequently asked questions about Zanaflex vs. Flexeril

Zanaflex has the potential to cause hypotension or abnormally low blood pressure. This effect typically manifests as orthostatic hypotension which occurs when a person moves to an upright position after lying down. In excess doses, Flexeril is also known to cause changes in blood pressure. It’s necessary to take cyclobenzaprine exactly as directed by your doctor to ensure safe usage.

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Additionally, methocarbamol can also be administered intravenously or intramuscularly, while dantrolene can be given intravenously, and baclofen can be given intrathecally. If you or a loved one is exhibiting one or more of these signs of cyclobenzaprine addiction, it might be time to consider professional support. A medical detox can help people with a cyclobenzaprine addiction safely undergo withdrawal in a clinically supervised setting. This is an important step in the process that can last up to 2 weeks after stopping cyclobenzaprine usage. When using the immediate-release tablets, consider less frequent dosing; initiate with 5-mg dose and increase slowly. Alternatively, may open capsules and sprinkle contents onto a tablespoon of applesauce and consume immediately without chewing; do not administer with any other food.

Coverage and cost comparison of Zanaflex vs. Flexeril

These medications should only be taken if their benefits outweigh the risks. Muscle relaxants should only be taken with medical guidance from a doctor. Since Robaxin and Flexeril have CNS depressant effects, they can interact with other drugs that have similar effects. Drugs that have CNS depressant effects include barbiturates and benzodiazepines.

Zanaflex only comes in immediate-release oral tablets and capsules while Flexeril comes in an extended-release capsule. Flexeril is known to cause serotonin syndrome, especially when taken with certain antidepressants, MAO inhibitors, and opioids. Signs and symptoms of serotonin syndrome should be monitored when starting treatment with Flexeril. Like other muscle relaxants, Zanaflex and Flexeril work in the central nervous system (CNS). Seek medical attention if symptoms of hepatic failure occur during therapy with this agent. 5 mg 3 times daily; may increase dosage to 10 mg 3 times daily depending on response.

• Seek medical attention if symptoms of hepatic failure occur during therapy with this agent.
• Cyclobenzaprine is a centrally acting skeletal muscle relaxant structurally related to tricyclic antidepressants.
• It primarily works on the brain stem and spinal cord in the CNS, which helps reduce motor activity.

It also comes as an oral capsule in strengths of 2 mg, 4 mg, and 6 mg. Not known whether cyclobenzaprine is distributed into milk; however, distribution into milk is possible, since other tricyclic drugs distribute into milk. Arrhythmias, sinus tachycardia, prolongation of the conduction how long after robaxin can i take flexeril time leading to MI, and stroke reported with tricyclic antidepressants. 15 mg once daily (at approximately the same time each day); some patients may require up to 30 mg once daily. There are no adequate studies to show that Robaxin or Flexeril are safe or harmful during pregnancy.

It is usually taken as a 2 mg or 4 mg tablet every six to eight hours. Overall, the study found that these drugs are comparable in efficacy and safety. Other guidelines suggest that muscle relaxants cause increased drowsiness and should only be used short-term. According to a meta-analysis, cyclobenzaprine has been studied in the most clinical trials with evidence to support its use. Tizanidine was shown to be effective for spasticity due to multiple sclerosis.

Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. Flexeril is one of the most studied muscle relaxants; thus, it has more supporting evidence for its effectiveness. In a systematic review, it was found that, in general, muscle relaxants are comparable in effectiveness. This review included other muscle relaxants such as metaxalone, baclofen, tizanidine, orphenadrine, and chlorzoxazone. Robaxin and Flexeril are FDA approved to treat discomfort or muscle spasms from acute musculoskeletal conditions as well as tetanus.

Also, cyclobenzaprine can cause dry mouth because it has anticholinergic effects. The risk of serious side effects and overdose from cyclobenzaprine increases when dangerous drug interactions occur. Patients should tell their doctors about any other prescriptions they’re taking before ingesting a muscle relaxant like cyclobenzaprine.